Sequencing for rapid response to Lassa fever
نویسندگان
چکیده
منابع مشابه
Pathogenesis of Lassa Fever
Lassa virus, an Old World arenavirus (family Arenaviridae), is the etiological agent of Lassa fever, a severe human disease that is reported in more than 100,000 patients annually in the endemic regions of West Africa with mortality rates for hospitalized patients varying between 5-10%. Currently, there are no approved vaccines against Lassa fever for use in humans. Here, we review the publishe...
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Lassa virus (LASV) is the most prominent human pathogen of the Arenaviridae. The virus is transmitted to humans by a rodent reservoir, Mastomys natalensis, and is capable of causing lethal Lassa Fever (LF). LASV has the highest human impact of any of the viral hemorrhagic fevers (with the exception of Dengue Fever) with an estimated several hundred thousand infections annually, resulting in tho...
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Vito Martella, Alessandro Bianchi, Irene Bertoletti, Luca Pedrotti, Alessandro Gugiatti, Alessia Catella, Paolo Cordioli, Maria S. Lucente, Gabriella Elia, and Canio Buonavoglia Author affi liations: Università di Bari, Bari, Italy (V. Martella, M.S. Lucente, G. Elia, C. Buonavoglia); Istituto Zooprofi lattico Sperimentale della Lombardia e dell’Emilia Romagna, Sezione di Sondrio, Italy (A. Bia...
متن کاملLassa Fever, Nigeria, 2005–2008
To the Editor: Lassa fever affects ≈100,000 persons per year in West Af-rica (1). The disease is caused by Las-sa virus, an arenavirus, and is associated with bleeding and organ failure. The case-fatality rate in hospitalized patients is 10%–20%. The reservoir of the virus is multimammate mice (Mastomys natalensis). Investigations in the 1970s and 1980s pointed to the existence of 3 disease-end...
متن کاملMastomys natalensis and Lassa Fever, West Africa
PCR screening of 1,482 murid rodents from 13 genera caught in 18 different localities of Guinea, West Africa, showed Lassa virus infection only in molecularly typed Mastomys natalensis. Distribution of this rodent and relative abundance compared with M. erythroleucus correlates geographically with Lassa virus seroprevalence in humans.
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ژورنال
عنوان ژورنال: Nature Medicine
سال: 2019
ISSN: 1078-8956,1546-170X
DOI: 10.1038/s41591-019-0363-0